Topics 2014-2015

Date Presenter Paper

Organizational meeting
Biomedical Research Facility II - 1104 8:00 am

Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper.

Fall 2014: Classic Papers

Date Presenter Paper
10/15/14 Babette Hammerling Meselson and Stahl (1958) The replication of DNA in Escherichiacoli. PNAS44: 671-682. [pdf]
10/22/14 Cynthia Hsu Brenner, Jacob, and Meselson (1961) An unstable intermediate carrying information form genes to ribosomes for protein synthesis. Nature 190: 576-581. [pdf]
10/29/14 Fernando Martinez Jackson, Symons and Berg (1972) Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. PNAS . [pdf]
11/5/14 Jaime Barea Beadle, G.W. and Tatum, E.L. (1941) Genetic control of biochemical reactions in Neurospora. PNAS 27: 499-506. [pdf]
11/12/14 Prof. Nik Schork

Responsible Conduct of Research: Managing Conflicts of Interest.

11/19/14 Micah Manary Sturetevant (1913) The linear arrangement of six sex-linked factors in Drosophila as shown by their mode of association. J. Exp. Zool. 14: 43-59.
journal [pdf] E.S.P. reprint [pdf]
12/3/14 Gabriel Pratt Needleman and Wunsch (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 43: 443-453. [pdf]
12/10/14 Eric Scott Sanger et al. (1977) Nucleotide sequence of bacteriophage phiX174 DNA.Nature 265: 687-695. [pdf]
12/17/14 Naomi Searle Hartwell, Culotti, and Reid. (1970) Genetic Control of the Cell-Division cycle in Yeast, I. Detection of Mutants. PNAS 66: 352-359. [pdf]
Winter Break Selection of Winter topic.

Winter 2015: Population Genetics

Date Presenter Paper
1/7/15 Michael Yu Huerta-Sánchez et al. (2014) Altitude adaptation in Tibetans casued by introgression of Denisovan-like DNA. Nature 512, 194–197.
1/14/15 Alexandra Buckley

Schaub et al. (2012) Linking disease associations with regulatory information in the human genome (Method). Genome Research 22, 1748-1759.

1/21/15 Victoria Corey Tishkoff et al. (2001) Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance.Science 293, 455-462.
1/28/15 Sophia Española Gurdasani et al (2015) The African Genome Variation Project shapes medical genetics in Africa. Nature 517, 327-332.
2/4/15 Kevin Ross Simons et al. (2014) The deleterious mutation load is insensitive to recent population history. Nature Genetics 46, 220-224.
2/11/15 Bernardo Lara King et al. (2015) Mosaic structural variation in children with developmental disorders. Human Mol. Genet. [pdf ahead of print]

Prof. Anthony Magit, MD, MPH
Director, Human Research Protection Program

Use of human subjects in genetics research.
2/25/15 Genevieve Ryan Schubert et al. (2014) Prehistoric genomes reveal the genetic foundation and cost of horse domestication. PNAS 111, E5661–E5669.
3/4/15 Sam Stoner Lamichhaney et al. (2015) Evolution of Darwin's finches and their beaks revealed by genome sequencing. Nature 518, 371-375.

Anthony Schmitt

Carbone et al. (2014) Gibbon genome and the fast karyotype evolution of small apes. Nature 513, 195-201.
Spring Break

Spring 2015: Agricultural Genetics

Date Presenter Paper
4/1/15 Lawrence Wong Shaatiel et al. (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnology Journal 5, 579-590.
4/8/15 Danny Antaki Pelsy et al. (2015) Chromosome replacement and deletion lead to clonal polymorphism of berry color in grapevine. PLOS Genetics 11, e1005081.
4/15/15 Daniel Chen Lyall et al. (2011) Suppression of Avian Influenza Transmission in Genetically Modified Chickens. Science 331, 223-226 .
4/22/15 Wilmer Del Cid Zheng et al. (2015) Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science 347, 991-994.
4/29/15 Prof. Michael Kalichman

Responsible Conduct of Research. What are appropriate safeguards and standards for environmental release of engineered orgnaisms and human germline interventions?

Assigned Papers:

  1. Glantz and Bier (2015) The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Science, Xpress online.
  2. Baltimore et al. (2015) A prudent path forward for genomic engineering and germline gene modification. Science 348:36-38.
  3. Lanphier et al. (2015) Don't edit the human germ line. Nature 519: 410-411.
5/6/15 Jennifer Kuo Mandell et al. (2015) Biocontainment of genetically modified organisms by synthetic protein design. Nature 518, 55–60.
Nathan Jameson Huang, X. et al. (2015) Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis. Nat. Commun. 6: 6258.
5/20/15 Terry Solomon Simcic et al. (2015) Recovery of native genetic background in admixed populations using haplotypes, phenotypes, and pedigree information - using cika cattle as a case breed. PLoS One. 10, e0123253.
Jenhan Tao Wang et al. (2014) Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotech.32, 947–951.
6/3/15 Tina Wang Kim et al. (2014) Genomic-scale exchange of mRNA between a parasitic plant and its hosts. Science 345, 808-811.

Faculty: Bruce Hamilton (Program Director), Richard Kolodner (Associate Director), Faculty Mentors.