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Topics 2007-2008

Date Presenter Paper

Organizational meeting

Introductions, Choose Fall topic, How to choose and critique a paper.

Fall 2007: Longevity and Ageing

Date Presenter Paper
10/10/07 Jarrod Heck Bishop and Guarente (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549.
10/17/07 Natalie Kardos Matheu et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448: 375-379.
10/24/07 Dustin Wakeman Postponed due to wildfires
10/31/07 Dustin Wakeman Molofsky et al. (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452.
11/7/07 Janine Low-Marchelli Kurosu et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309: 1829-1833.
11/14/07 Madeline Lancaster Conti et al. (2006) Transgenic mice with a reduced core body temperature have an increased life span. Science 314: 825-828.
11/28/07 Kelly Lagor Cao et al. (2007) A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells. PNAS 104: 4949-4954.
12/5/07 Molly Bush Libert et al. (2007) Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors. Science 315: 1133-1137.

Ohn Chow

Trifunovic et al. (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. PNAS 102: 17993-17998.
Winter Break

Winter 2008: Cancer Genetics

Date Presenter Paper
1/9/08 Dan Clark

Khetchoumian et al. (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature Genetics 39: 1500-1506.

1/16/08 Ali Torkamani Wood et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113.
1/23/08 Stephen Cheng Ma et al. (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688.
1/30/08 Tom Cohen Gazin et al. (2007) An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449: 1073-1077.
2/6/08 Rafael Gomez-Amaro Krimpenfort et al. (2007) p15ink4b is a critical tumor suppressor in the absence of p16ink4a. Nature 448: 943-946.
2/13/08 Stephanie Nissen Pruitt et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genetics 2: e40.
2/20/08 Morgan Pence Cortina et al. (2007) EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nature Genetics 39: 1376-1383.
2/27/08 Marie Reichert Xue et al. (2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.Nature 445: 656-660.
3/5/08 Eveline Sun Pinkston-Gosse, J. and Kenyon, C. (2007) DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nature Genetics 39: 1403 - 1409.

Shannon Weiman

Mahller et al. (2008) Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. Cancer Research 68: 1170-1179.
3/19/08 Group: classic paper

Knudson, A.G. (1971) Mutation and Cancer: Statistical Study of Retinoblastoma. PNAS 68: 820-823.

Spring Break

Spring 2008: Plant Genetics

Date Presenter Paper
4/2/08 Molly Bush Xiao et al. (2008) A Retrotransposon-mediated gene duplication underlies morphological variation of tomato fruit. Science 319: 1527-1530.
4/9/08 Ohn Chow Bastow et al. (2004) Vernalization requires epigenetic silencing of FLC by histone methylation. Nature 427: 164-167.
4/16/08 Dan Clark Dodd et al. (2005) Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309: 630-633.
4/23/08 Stephen Cheng Molinier et al. (2006) Transgeneration memory of stress in plants. Nature 442: 1046-1049.
4/30/08 Tom Cohen Harjes et al. (2008) Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science 319: 330-333.
5/7/08 Rafael Gomez-Amaro Chinchilla et al. (2007) A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature 448: 497-500.
5/14/08 Eveline Sun Toby et al. (2008) cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids. PNAS 105: 4553-4558.
5/21/08 Morgan Pence Manning et al. (2006) A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nature Genetics 38: 948-952.
5/28/08 Marie Reichert

Palatnik et al. (2003) Control of leaf morphogenesis by microRNAs. Nature 425: 257-263.

6/4/08 Stephanie Nissen Fujimoto et al. (2008) Evolution and control of imprinted FWA genes in the genus Arabidopsis. PLoS Genetics 4: e1000048.
6/11/08 Shannon Weiman Kimura et al (2008) Natural variation in leaf morphology results from mutation of a novel KNOX gene. Current Biol.

Faculty: Bruce Hamilton (Course Director), Steve Dowdy, Larry Goldstein, Yishi Jin, Jing Yang