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Topics 2004-2005

Fall 2004: Meiosis and Recombination

Date Presenter Paper
10/1/04 Joost Monen Tóth et al. (2000) Functional Genomics Identifies Monopolin: A Kinetochore Protein Required for Segregation of Homologs during Meiosis I. Cell 103: 1155-1168.
10/8/04 Nichol Goodman Miller Reddy and Villenueve (2004) C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination. Cell 118: 439-452.
10/15/04 Michelle Mendoza Ben-Aroya et al. (2004) The Compact Chromatin Structure of a Ty Repeated Sequence Suppresses Recombination Hotspot Activity in Saccharomyces cerevisiae. Molecular Cell 15: 221-231.
10/22/04 Will Alaynick Borner et al. (2004) Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis. Cell 117: 29-45.
see also Review by Bishop and Zickler.
10/29/04 Stefan Aung Rabitsch et al. (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev. Cell 4(4): 535-548. See also erratum for Figure 6 in Dev. Cell. 5: 523.
11/5/04 Stephanie Bielas Revenkova et al. (2004) Cohesin SMC1 beta is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination. Nat. Cell Biol. 6: 555-562.
11/12/04 Adam Bouton Gabriel et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2259.
11/19/04 Minh-ha Do Crackower et al. (2003) Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science 300: 1291-1295.

Mike Hannon

Kong et al. (2004) Recombination rate and reproductive success in humans. Nature Genetics 36: 1203-1206.
12/10/04 Edmund Hollis Chan et al. (2004) Condensin restructures chromosomes in preparation for meiotic divisions. J. Cell Biol. 167: 613-625.
12/17/04 Steve Miller Mehlmann et al. (2004) The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306: 1947-1950.
Winter Break

Winter-Spring 2005: Epigenetics

Date Presenter Paper
1/7/05 Nate Heintzman

Satoh et al. (2004) Epigenetic inactivation of class II transactivator (CIITA) is associated with the absence of interferon-c-induced HLA-DR expression in colorectal and gastric cancer cells. Oncogene 23: 8876-8886.

1/14/05 Scarlet Shell Shi et al. (2004) Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1. Cell 119: 941-953.
1/21/05 Alain Silk Weaver et al. (2004) Epigenetic programming by maternal behavior. Nature Neuroscience 7: 847-854.
1/28/05 Ambika Sundarasen Kawasaki and Taira (2004) Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature 431: 211-217.
2/4/05 Ann Valle Herman et al. (2003) Trans allele methylation and paramutation-like effects in mice. Nature Genetics 34: 199-202.
2/11/05 Harper VanSteenhouse Ronshaugen M, Levine M. (2004) Visualization of trans-homolog enhancer-promoter interactions at the Abd-B Hox locus in the Drosophila embryo. Dev. Cell 7: 925-932.
2/18/05 Michelle Wagner Okamoto et al. (2004) Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303: 644-649.
2/25/05 Wendy Books Kantor, et al. (2004) Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo. Human Molecular Genetics 13: 2767-2779.
3/4/05 Matt Busse Rohde and Cardenas (2003) The Tor Pathway Regulates Gene Expression by Linking Nutrient Sensing to Histone Acetylation. Mol. Cell. Biol. 23: 629-635.

Tony Essex

Nolen et al. (2005) X chromosome reactivation and regulation in cloned embryos. Dev. Biol. 279: 525-540.

Jason Goode

Schmitt et al. (2005) Intergenic transcription through a Polycomb group response element counteracts silencing. Genes Dev. (EPUB ahead of print)
final print version: Genes Dev. 19: 697-708.
Spring Break
4/1/05 Lindsay Lewellyn Verdel et al. (2004) RNAi-Mediated Targeting of Heterochromatin by the RITS complex. Science 303: 672-676.
4/8/05 Carrie Louie Horike et al. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nature Genetics 37: 31-40 see News & Views by Pescucci et al.
4/15/05 Rany Salem Hinds et al. (2005) Whole-genome patterns of common DNA variation in three human populations. Science 307: 1072-1079
4/22/05 Group discussion Lolle et al. (2005) Genome-wide non-mendelian inheritance of extra-genomic information in Arabidopsis. Nature 434: 505-509 see News & Views by Weigel and Jurgens
4/29/05 Alaynick / Aung Research talks
5/6/05 Bielas / Bouton Research talks
5/13/05 Busse / Gonzalez Research talks
5/20/05 N. G. Miller / Hannon Research talks
5/27/05 Heintzman / Mendoza Research talks
6/3/05 S. Miller / Silk Research talks
6/10/05 Valle / Wagner Research talks

Faculty: Bruce Hamilton (course director), Anthony Wynshaw-Boris