Topics 2005-2006

Date Presenter Paper

Organizational meeting

Introductions, Choose Fall topic, How to choose and critique a paper.

Fall 2005: Host-Pathogen Interactions and Immunogenetics

Date Presenter Paper
9/30/05 Scarlet Shell Malik et al. (2005) Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci USA. 102: 12183-8.
10/7/05 Min-ha Do Hladik et al. (2005) Combined Effect of CCR5-delta32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission. J Virol. 79: 11677-84.
10/14/05 Edmund Hollis Taubenberger et al. (2005) Characterization of the 1918 influenza virus polymerase genes. Nature 437: 889-893.
10/21/05 Joost Monen Rangarajan et al. (2005) A mitogen-activated protein kinase regulates male gametogenesis and transmission of themalaria parasite Plasmodium berghei. EMBO Reports 6: 464-469.
10/28/05 Ambika Sundarasen Curran et al. (2005) Genetic variation in selenoprotein S influences inflammatory response. Nature Genetics 37: 1234-1241. [online ahead of print, October 9.]
11/4/05 Dustin Wakeman East et al. (2005) A Role for the Plasminogen Activator System in Inflammation and Neurodegeneration in the Central Nervous System during Experimental Allergic Encephalomyelitis. Am. J. Pathol. 167: 545-554.
Veteran's Day
11/18/05 Wendy Books Tumpey et al. (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310: 77-80.
12/2/05 Tony Essex Jopling et al. (2005) Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA. Science 309: 1577-1581.
12/9/05 Jason Goode Watson et al. (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309: 1874-1878.
12/16/05 Lindsay Lewellyn Freitas-Junior et al. (2005) Telomeric Heterochromatin Propagation and Histone Acetylation Control Mutually Exclusive Expression of Antigenic Variation Genes in Malaria Parasites. Cell 121: 25-36.
Winter Break

Winter 2006: Mitochondrial Genetics

Date Presenter Paper
1/6/06 Carrie Louie

Kujoth et al. (2005) Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging.Science 309: 481-484.

1/13/06 Rany Salem Ingman et al. (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408: 708-713.
1/20/06 Harper VanSteenhouse Kravchenko et al. (2005) Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Nature 436: 735-739.
1/27/06 Emily Davis Krause et al. (2005) Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae.Nature published online 18 December 2005 | doi:10.1038/nature04432
2/3/06 Jarrod Heck Zsurka et al. (2005) Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy. Nature Genetics 37: 873-877.
2/10/06 Natalie Kardos Sato et al. (2005) Rare creation of recombinant mtDNA haplotypes in mammalian tissues. Proc Natl Acad Sci USA.102: 6057-6062.
2/17/06 Alice Kiselyuk Simmons et al. (2005) Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to Beta-Cell Failure. J. Biol. Chem. 280: 28785-28791.

Spring 2006: Gene Therapy

Date Presenter Paper
2/24/06 Kelly Lagor Acland et al. (2005) Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics 28: 92-95.
3/3/06 Madeline Lancaster

Passini et al. (2006) Intracranial Delivery of CLN2 Reduces Brain Pathology in a Mouse Model of Classical Late Infantile Neuronal Ceroid Lipofuscinosis. J. Neurosci. 26: 1334-1342.

3/10/06 Janine Low Kato et al. (2005) Nonviral Gene Transfer of Human Hepatocyte Growth Factor Improves Streptozotocin-Induced Diabetic Neuropathy in Rats. Diabetes 54: 846-854.
3/17/06 Wendy Books Maheshri et al. (2006) Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nature Biotechnology 24: 198 - 204.
3/24/06 Tony Essex Aiuti et al. (2002) Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning. Science 296: 2410-2413.
Spring Break
4/7/06 Jason Goode Cole et al. (2005) Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. Nature Medicine 11: 1073-1081.
4/14/06 Lindsay Lewellyn Ndoye et al. (2006) Eradication of p53-Mutated Head and Neck Squamous Cell Carcinoma Xenografts Using Nonviral p53 Gene Therapy and Photochemical Internalization.Molecular Therapy in press
4/21/06 Carrie Louie Samakoglu et al. (2005) A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference. Nature Biotechnology 24: 89-94.
4/28/06 Rany Salem Li et al. (2005) Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Molecular Therapy 12: 900-909.
5/5/06 Harper VanSteenhouse Research talk
5/12/06 Joost Monen Research talk
5/19/06 Edmund Hollis Research talk
5/26/06 Min-ha Do Research talk
6/2/06 Scarlett Shell Research talk
6/9/06 Ambika Sundarasen Research talk

Faculty: Bruce Hamilton (Course Director), Anthony Wynshaw-Boris