Topics 2005-2006
| Date | Presenter | Paper |
| 9/23/05 |
Organizational meeting |
Introductions, Choose Fall topic, How to choose and critique a paper. |
Fall 2005: Host-Pathogen Interactions and Immunogenetics
| Date | Presenter | Paper |
| 9/30/05 | Scarlet Shell | Malik et al. (2005) Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc Natl Acad Sci USA. 102: 12183-8. |
| 10/7/05 | Min-ha Do | Hladik et al. (2005) Combined Effect of CCR5-delta32 Heterozygosity and the CCR5 Promoter Polymorphism -2459 A/G on CCR5 Expression and Resistance to Human Immunodeficiency Virus Type 1 Transmission. J Virol. 79: 11677-84. |
| 10/14/05 | Edmund Hollis | Taubenberger et al. (2005) Characterization of the 1918 influenza virus polymerase genes. Nature 437: 889-893. |
| 10/21/05 | Joost Monen | Rangarajan et al. (2005) A mitogen-activated protein kinase regulates male gametogenesis and transmission of themalaria parasite Plasmodium berghei. EMBO Reports 6: 464-469. |
| 10/28/05 | Ambika Sundarasen | Curran et al. (2005) Genetic variation in selenoprotein S influences inflammatory response. Nature Genetics 37: 1234-1241. [online ahead of print, October 9.] |
| 11/4/05 | Dustin Wakeman | East et al. (2005) A Role for the Plasminogen Activator System in Inflammation and Neurodegeneration in the Central Nervous System during Experimental Allergic Encephalomyelitis. Am. J. Pathol. 167: 545-554. |
| Veteran's Day | ||
| 11/18/05 | Wendy Books | Tumpey et al. (2005) Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 310: 77-80. |
| Thanksgiving | ||
| 12/2/05 | Tony Essex | Jopling et al. (2005) Modulation of Hepatitis C Virus RNA Abundance by a Liver-Specific MicroRNA. Science 309: 1577-1581. |
| 12/9/05 | Jason Goode | Watson et al. (2005) Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science 309: 1874-1878. |
| 12/16/05 | Lindsay Lewellyn | Freitas-Junior et al. (2005) Telomeric Heterochromatin Propagation and Histone Acetylation Control Mutually Exclusive Expression of Antigenic Variation Genes in Malaria Parasites. Cell 121: 25-36. |
| Winter Break |
Winter 2006: Mitochondrial Genetics
| Date | Presenter | Paper |
| 1/6/06 | Carrie Louie |
Kujoth et al. (2005) Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging.Science 309: 481-484. |
| 1/13/06 | Rany Salem | Ingman et al. (2000) Mitochondrial genome variation and the origin of modern humans. Nature 408: 708-713. |
| 1/20/06 | Harper VanSteenhouse | Kravchenko et al. (2005) Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin. Nature 436: 735-739. |
| 1/27/06 | Emily Davis | Krause et al. (2005) Multiplex amplification of the mammoth mitochondrial genome and the evolution of Elephantidae.Nature published online 18 December 2005 | doi:10.1038/nature04432 |
| 2/3/06 | Jarrod Heck | Zsurka et al. (2005) Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy. Nature Genetics 37: 873-877. |
| 2/10/06 | Natalie Kardos | Sato et al. (2005) Rare creation of recombinant mtDNA haplotypes in mammalian tissues. Proc Natl Acad Sci USA.102: 6057-6062. |
| 2/17/06 | Alice Kiselyuk | Simmons et al. (2005) Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to Beta-Cell Failure. J. Biol. Chem. 280: 28785-28791. |
Spring 2006: Gene Therapy
| Date | Presenter | Paper |
| 2/24/06 | Kelly Lagor | Acland et al. (2005) Gene therapy restores vision in a canine model of childhood blindness. Nature Genetics 28: 92-95. |
| 3/3/06 | Madeline Lancaster |
Passini et al. (2006) Intracranial Delivery of CLN2 Reduces Brain Pathology in a Mouse Model of Classical Late Infantile Neuronal Ceroid Lipofuscinosis. J. Neurosci. 26: 1334-1342. |
| 3/10/06 | Janine Low | Kato et al. (2005) Nonviral Gene Transfer of Human Hepatocyte Growth Factor Improves Streptozotocin-Induced Diabetic Neuropathy in Rats. Diabetes 54: 846-854. |
| 3/17/06 | Wendy Books | Maheshri et al. (2006) Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. Nature Biotechnology 24: 198 - 204. |
| 3/24/06 | Tony Essex | Aiuti et al. (2002) Correction of ADA-SCID by Stem Cell Gene Therapy Combined with Nonmyeloablative Conditioning. Science 296: 2410-2413. |
| Spring Break | ||
| 4/7/06 | Jason Goode | Cole et al. (2005) Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells. Nature Medicine 11: 1073-1081. |
| 4/14/06 | Lindsay Lewellyn | Ndoye et al. (2006) Eradication of p53-Mutated Head and Neck Squamous Cell Carcinoma Xenografts Using Nonviral p53 Gene Therapy and Photochemical Internalization.Molecular Therapy in press |
| 4/21/06 | Carrie Louie | Samakoglu et al. (2005) A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference. Nature Biotechnology 24: 89-94. |
| 4/28/06 | Rany Salem | Li et al. (2005) Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy. Molecular Therapy 12: 900-909. |
| 5/5/06 | Harper VanSteenhouse | Research talk |
| 5/12/06 | Joost Monen | Research talk |
| 5/19/06 | Edmund Hollis | Research talk |
| 5/26/06 | Min-ha Do | Research talk |
| 6/2/06 | Scarlett Shell | Research talk |
| 6/9/06 | Ambika Sundarasen | Research talk |
Faculty: Bruce Hamilton (Course Director), Anthony Wynshaw-Boris