Topics 2008-2009

Date Presenter Paper

Organizational meeting

Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper.

Fall 2008: RNA Genetics

Date Presenter Paper
10/8/08 Tom Cohen Brouns et al. (2008) Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes. Science 321: 960-964.
10/15/08 Molly Bush Merritt et al. (2008) 3' UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline. Current Biol.18: 1–7.
10/22/08 Ohn Chow Lecellier et al. (2005) A Cellular MicroRNA Mediates Antiviral Defense in Human Cells. Science 308: 557-560.
10/29/08 Michael Kalichman Case discussion: Human Subjects and Informed Consent in Genetic Research Resources for Research Ethics Education
11/5/08 Dan Clark Chen and Zheng (2008) Identify alternative splicing events based on position-specific evolutionary conservation. PLoS ONE 3: e2806.
11/12/08 Rafael Gomez-Amaro Tay et al. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiationNature 455: 1124-1128.
11/19/08 Stephanie Nissen Marengo and Wassarman (2008) A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing. RNA 14: 1681-1695.
12/3/08 Britt Flaherty Goncalves et al. (2008) The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA 14: 2538-2549.
12/10/08 Morgan Pence Saraiya and Wang (2008) snoRNA, a Novel Precursor of microRNA in Giardia lamblia. PLoS Pathogens 4: e1000224

Eveline Sun

Lee et al. (2008) miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.Nature Neuroscience 11: 1137-1139.
Winter Break

Winter 2009: Evolutionary and Comparative Genetics

Date Presenter Paper
1/14/09 Taylor Bright

Mu et al. (2005) Host Switch Leads to Emergence ofPlasmodium vivax Malaria in Humans. Mol. Biol. Evol. 22: 1686-1693.

1/21/09 Michael Kalichman

Case discussion: Science and Public Policy

1/28/09 David Kochman Smukalla et al. (2008) FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast. Cell135: 726-737.
2/4/09 Julianne McCall Krause et al. (2007) The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals. Curr. Biol. 17: 1908-1912.
2/11/09 Jeff Nelson Gerke et al. (2009) Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast.Science 323: 498 - 501.
2/18/09 Pagkapol Pongsawakul

Tauber et al. (2007) Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster. Science316: 1895-1897.

Sandrelli et al. (2007) A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster.Science 316: 1897-1900.

2/25/09 Erilynn Russo Perry et al. (2008) Copy number variation and evolution in humans and chimpanzees. Genome Research 18: 1698-1710.
3/4/09 Deanna Stevens Wang et al. (2009) Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance. BMC Evol. Biol. 9: 23 doi:10.1186/1471-2148-9-23
3/11/09 Emily Witham Haygood et al. (2007) Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution. Nature Genetics 39: 1140-1144.

Spring 2009: Classic Papers in Genetics

Date Presenter Paper
3/18/09 Ohn Chow Luria and Delbrück (1943) Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics 28: 491-511.
Spring Break
4/1/09 Leah Boyer McClintock (1950) The Origin and Behavior of Mutable Loci in Maize. PNAS 36: 344-355.
4/8/09 Tom Cohen Hartwel et al. (1970) Genetic control of cell division in yeast, I. Detection of mutants. PNAS 66: 352-359.
4/15/09 Rafael Gomez-Amaro Nüsslein-Volhard and Wieschaus (1980) Mutations affecting segmentnumber and polarity in Drosophila. Nature 287: 795-801.
4/22/09 Stephanie Nissen Sturtevant (1913) The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association.J. Exp. Zool. 14: 43-59.
4/29/09 Morgan Pence Avery et al. (1944) Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types:
Induction of Transformation by a Desoxyribonucleic Acid Faction Isolated from Pneumococcus Type III. J. Exp. Med. 79: 137-158.
5/6/09 Eveline Sun Lewis (1978) A gene complex controlling segmentation inDrosophila. Nature 276: 565-570.
5/13/09 Taylor Bright Hershey and Chase (1952) Independent functions of viral protein and nucleic acid in growth of bacteriophage. J. Gen. Physiol. 36: 39-56.
5/20/09 Britt Flaherty Fire et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
5/27/09 David Kochman Muller (1918) Genetic variability, twin hybrids and constant hybrids, in a case of balanced lethal factors. Genetics 3: 422-499.
6/3/09 UCSD Institute for Genomic Medicine and J. Craig Venter Institute Joint Symposium

"Genome Frontiers in Human Health and Disease"
Institute of the Americas, UCSD
8:00 am – 5:30 pm

6/10/09 Jeff Nelson Pauling et al. (1949) Sickle Cell Anemia, a Molecular Disease. Science 110: 543-548.

Faculty: Bruce Hamilton (Program Director), Richard Kolodner (Associate Director), Elizabeth Winzeler, Ben Yu, Tracy Johnson, Sylvia Evans, John Kelsoe, Michael Kalichman, Steve Briggs