Journal Club

Fall 2016 - Analysis of Failure

What can we learn about best practices from acknowledged errors?

September 28: Organizational Meeting.
Introductions, GTP advising committee, how to critique a paper, selection of Fall topic.

October 5: Danny Antaki
Overview: Casadevall (2016) A Framework for Improving the Quality of Research in the Biological Sciences. mBio 7, e01256-16.
Paper: Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brain. PNAS (2014) Retracted.

October 12: Daniel Chen
DNA methylation age of human tissues and cell types. Genome Biology (2015) Published erratum.

October 19: Kristin Withers
Genetic Signatures of Exceptional Longevity in Humans. Science (2010) Retracted.

October 26: Jennifer Kuo
Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes & Development (2010) Retracted in light of later data:
A Critical Analysis of Atoh7 (Math5) mRNA Splicing in the Developing Mouse Retina. PLOS One (2010)

November 2: Terry Solomon
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant. PLOS Pathogens (2006) Retracted.

November 9: Jenhan Tao
Structure of MsbA from E. coli: A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters. Science (2001) Retracted. See also.

November 16: Tina Wang
Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells. Nature (2005) Retracted.

November 23: No class - Happy Thanksgiving.

November 30: Responsible Conduct of Research Discussion
Find your failures faster - design, validation, and review practices to minimize publication errors.
Professors Chi, Glass, Hamilton, Jin, and Wasserman.

Winter 2017 - Personal Genomes

January 11: Michael Baughn
Hoch et al. (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature 541, 87-91.

January 18: Spencer Goodman
Jones et al. (2015) Personalized genomic analyses for cancer mutation discovery and interpretation. Science Translational Medicine 7, 283ra53.

January 25: Samuel Lin
Minikel et al. (2016) Quantifying prion disease penetrance using large population control cohorts. Science Translational Medicine 8, 322ra9.

February 1: Alannah Miranda
Chen et al. (2016) Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases. Nature Biotech 34, 531-538.

February 8: Shanna Newton
Chong et al. (2016) Gene discovery for Mendelian conditions via social networking: de novo variants in KDM1A cause developmental delay and distinctive facial features. Genetics in Medicine 18, 788-795.

February 15: Alison Parisian
Zanoni et al. (2016) Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 351, 1166-1171.

February 22: Brian Reilly
Abraham et al. (2014) Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning. PLOS Genetics 10, e1004137.

March 1: Emily Wheeler
Reuter et al. (2016) Simul-seq: combined DNA and RNA sequencing for whole-genome and transcriptome profiling. Nature Methods 13, 953–958.

March 8: Responsible Conduct of Research Discussion
Julie Cakici, Project Manager, Rady Children’s Institute for Genomic Medicine.

March 15: Carolina Galarreta
Bodian et al. (2016) Utility of whole-genome sequencing for detection of newborn screening disorders in a population cohort of 1,696 neonates. Genetics in Medicine


Spring 2017 - Genetics of Infectious Disease

April 5: Andrew Cooper

April 12: Elie Farah

April 19: Nina Gao

April 26: Shereen Georges

May 3: Natalie Hollingsworth

May 10: Ryan Marina

May 17: Caroline Sferrazza

May 24: Mike Vaill

May 31: Responsible Conduct of Research Discussion