Fall 2016 - Analysis of Failure
What can we learn about best practices from acknowledged errors?
September 28: Organizational Meeting.
Introductions, GTP advising committee, how to critique a paper, selection of Fall topic.
October 5: Danny Antaki
Overview: Casadevall (2016) A Framework for Improving the Quality of Research in the Biological Sciences. mBio 7, e01256-16. http://mbio.asm.org/content/7/4/e01256-16.full
Paper: Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brain. PNAS (2014) http://dx.doi.org/10.1073/pnas.1404082111. Retracted.
October 26: Jennifer Kuo
Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes & Development (2010) http://dx.doi.org/10.1101/gad.1847110. Retracted in light of later data:
A Critical Analysis of Atoh7 (Math5) mRNA Splicing in the Developing Mouse Retina. PLOS One (2010) http://dx.doi.org/10.1371/journal.pone.0012315
November 2: Terry Solomon
Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant. PLOS Pathogens (2006) http://dx.doi.org/10.1371/journal.ppat.0020025. Retracted.
November 9: Jenhan Tao
Structure of MsbA from E. coli: A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters. Science (2001) http://dx.doi.org/10.1126/science.293.5536.1793. Retracted. See also.
November 23: No class - Happy Thanksgiving.
November 30: Responsible Conduct of Research Discussion
Find your failures faster - design, validation, and review practices to minimize publication errors.
Professors Chi, Glass, Hamilton, Jin, and Wasserman.
Winter 2017 - Personal Genomes
January 11: Michael Baughn
Hoch et al. (2017) XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia. Nature 541, 87-91.
January 18: Spencer Goodman
Jones et al. (2015) Personalized genomic analyses for cancer mutation discovery and interpretation. Science Translational Medicine 7, 283ra53.
January 25: Samuel Lin
Minikel et al. (2016) Quantifying prion disease penetrance using large population control cohorts. Science Translational Medicine 8, 322ra9.
February 1: Alannah Miranda
Chen et al. (2016) Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases. Nature Biotech 34, 531-538.
February 8: Shanna Newton
Chong et al. (2016) Gene discovery for Mendelian conditions via social networking: de novo variants in KDM1A cause developmental delay and distinctive facial features. Genetics in Medicine 18, 788-795.
February 15: Alison Parisian
Zanoni et al. (2016) Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 351, 1166-1171.
February 22: Brian Reilly
Abraham et al. (2014) Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning. PLOS Genetics 10, e1004137.
March 1: Emily Wheeler
March 8: Responsible Conduct of Research Discussion
March 15: Carolina Galarreta
Spring 2017 - TBA, dates tentative
April 5: Andrew Cooper
April 12: Elie Farah
April 19: Nina Gao
April 26: Shereen Georges
May 3: Natalie Hollingsworth
May 10: Ryan Marina
May 17: Caroline Sferrazza
May 24: Mike Vaill
May 31: Responsible Conduct of Research Discussion