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Journal Club

Fall 2018 - Psychiatric Genetics

October 3: Organizational Meeting
Introductions, GTP advising committee, Program expectations, How to critique a paper, Selection of Fall topic.

October 10: Shereen Ghosh, Gleeson Lab
Wray et al. (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics 50, 668–681. [bioRxiv]

October 17: Nina Gao, Nizet Lab
Deshpande et al. (2017) Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Reports 21, 2678-2687. [open access article]

October 24: Elie Farah, Chi Lab
Forrest et al. (2017) Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Cell Stem Cell. 21, 305-318. [open access article]

October 31: Natalie Hollingsworth, Oegema Lab
Scarpa et al. (2018) Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression. Sciences Advances 4, eaat1294. [PMC]

November 7: Ryan Marina, Yeo Lab
Dong et al. (2018) Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience 21, 1482-1492.

November 14: Caroline Sferrazza, Goldstein Lab
Skene et al. (2018) Genetic identification of brain cell types underlying schizophrenia. Nature Genetics 50, 825-833. [bioRxiv]

November 21: Thanksgiving Holiday

November 28: Mike Vaill, Varki Lab
Domínguez-Iturza et al. (2018) The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity. Pre-print [bioRxiv] [download pdf]

December 5: Abraham Palmer, Professor and Vice-Chair, Department of Psychiatry
Responsible Conduct of Research Discussion: Human germline selection and modification.

December 12: Mike Valdez, Sun Lab
The Brainstorm Consortium: Anttila et al. (2018) Analysis of shared heritability in common disorders of the brain. Science 360, eaap8757. [bioRxiv].
Select Winter topic.

Winter 2019 - Genetics of Domestication

January 9: Joshua Chiou, Gaulton Lab
Wu et al. (2018) Genomics of the origin and evolution of Citrus. Nature 554, 311-316. [open access article]

January 16: Ryan Geusz, Sander Lab
VanBuren et al. (2015) Origin and domestication of papaya Yh chromosome. Genome Research 25, 524-533. [PMC]

January 23: Emily Griffin, Ackerman Lab
Pendleton et al. (2018) Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication. BMC Biology 16, 64. [open access article]

January 30: Krystyna Kolodziej, Mukamel & Ren Labs
vonHoldt et al. (2017) Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs. Science Advances 3, e1700398. [UCLA escholarship]

February 6: Madeline Luth, Winzeler Lab
Wang et al (2018) Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes). PNAS 115, 10398-10403. [bioRxiv]

February 20: Noorsher Ahmed, Yeo Lab
Cornejo et al. (2018) Population genomic analyses of the chocolate tree, Theobroma cacao L., provide insights into its domestication process. Communications Biology 1, 167. [open access article]

February 27: Saugat Poudel, Nizet Lab
Schubert et al. (2014) Prehistoric genomes reveal the genetic foundation and cost of horse domestication. PNAS 111, E5661-E5669. [PMC]

March 6: Responsible Conduct of Research Discussion
Faculty panel: Friedmann, Hamilton, Sun, Winzeler. Peer Review standards and practice.

COPE Ethical Guidelines for Peer Reviewers [pdf]

March 13: Xinzhu Zhou, Palmer Lab
Leathlobhair et al. (2018) The evolutionary history of dogs in the Americas. Science 361, 81-85. [preprint via Apollo]

Select Spring quarter topic.

Spring 2019 - Classic Papers

April 3: Melinda Beccari, Cleveland Lab
McClintock (1950) The origin and behavior of mutable loci in maize. PNAS 36, 344-355. [pdf]

April 10: Tunmise Olayinka, Muotri Lab
Cox et al. (1990) Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science 250, 245-250. [pdf]

April 17: Corina Elder, Pasquinelli Lab
Crick et al. (1961) General nature of the genetic code for proteins. Nature 192, 1227-32. [pdf]

April 24: Margaret Burns, Yeo Lab
Bridges (1913) Non-disjunction of the sex chromosomes of Drosophila. J. Exp. Zool. 15, 587-606. [pdf]

May 1: Jessica Bloom, Rifkin Lab
Dobzhansky and Spassky (1962) Genetic drift and natural selection in experimental populations of Drosophila pseudoobscura. PNAS 48, 148-156. [pdf]

May 8: Emily Ho, Mellon Lab
Beadle and Tatum (1941) Genetic control of biochemical reactions in Neurospora. PNAS 27, 499-506. [pdf]

May 15: James Hocker, Ren Lab
Luria and Delbruck (1943) Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics 28, 491-511. [pdf]

May 22: Erin Ritchie, Jin Lab
Altenberg, E. and Muller, H.J. (1915) The genetic basis of truncate wing,- an inconstant and modifiable character in Drosophila. Genetics 5:1-59. [pdf]

May 29: Zeyang Shen, Glass Lab
Fire et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811. [pdf]

June 5: Responsible Conduct of Research Discussion
Elizabeth Winzeler. Implicit bias in scientific review. Asplund and Welle (2018) [pdf]

June 12: Yilan Shi, Yeo Lab
Brenner et al. (1961) An unstable intermediate carrying information from genes to ribosomes for protein synthesis. Nature 190, 576-581. [pdf] [CSHL archive]