| Date | Presenter | Paper |
| 10/3/07 |
Organizational meeting |
Introductions, Choose Fall topic, How to choose and critique a paper. |
| Date | Presenter | Paper |
| 10/10/07 | Jarrod Heck | Bishop and Guarente (2007) Two neurons mediate diet-restriction-induced longevity in C. elegans. Nature 447: 545-549. |
| 10/17/07 | Natalie Kardos | Matheu et al. (2007) Delayed ageing through damage protection by the Arf/p53 pathway. Nature 448: 375-379. |
| 10/24/07 | Dustin Wakeman | Postponed due to wildfires |
| 10/31/07 | Dustin Wakeman | Molofsky et al. (2006) Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443: 448-452. |
| 11/7/07 | Janine Low-Marchelli | Kurosu et al. (2005) Suppression of aging in mice by the hormone Klotho. Science 309: 1829-1833. |
| 11/14/07 | Madeline Lancaster | Conti et al. (2006) Transgenic mice with a reduced core body temperature have an increased life span. Science 314: 825-828. |
| Thanksgiving | ||
| 11/28/07 | Kelly Lagor | Cao et al. (2007) A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells. PNAS 104: 4949-4954. |
| 12/5/07 | Molly Bush | Libert et al. (2007) Regulation of Drosophila Life Span by Olfaction and Food-Derived Odors. Science 315: 1133-1137. |
| 12/12/07 |
Ohn Chow |
Trifunovic et al. (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. PNAS 102: 17993-17998. |
| Winter Break |
| Date | Presenter | Paper |
| 1/9/08 | Dan Clark |
Khetchoumian et al. (2007) Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nature Genetics 39: 1500-1506. |
| 1/16/08 | Ali Torkamani | Wood et al. (2007) The genomic landscapes of human breast and colorectal cancers. Science 318: 1108-1113. |
| 1/23/08 | Stephen Cheng | Ma et al. (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688. |
| 1/30/08 | Tom Cohen | Gazin et al. (2007) An elaborate pathway required for Ras-mediated epigenetic silencing. Nature 449: 1073-1077. |
| 2/6/08 | Rafael Gomez-Amaro | Krimpenfort et al. (2007) p15ink4b is a critical tumor suppressor in the absence of p16ink4a. Nature 448: 943-946. |
| 2/13/08 | Stephanie Nissen | Pruitt et al. (2006) Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genetics 2: e40. |
| 2/20/08 | Morgan Pence | Cortina et al. (2007) EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nature Genetics 39: 1376-1383. |
| 2/27/08 | Marie Reichert | Xue et al. (2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas.Nature 445: 656-660. |
| 3/5/08 | Eveline Sun | Pinkston-Gosse, J. and Kenyon, C. (2007) DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nature Genetics 39: 1403 - 1409. |
| 3/12/08 |
Shannon Weiman |
Mahller et al. (2008) Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. Cancer Research 68: 1170-1179. |
| 3/19/08 | Group: classic paper |
Knudson, A.G. (1971) Mutation and Cancer: Statistical Study of Retinoblastoma. PNAS 68: 820-823. |
| Spring Break |
| Date | Presenter | Paper |
| 4/2/08 | Molly Bush | Xiao et al. (2008) A Retrotransposon-mediated gene duplication underlies morphological variation of tomato fruit. Science 319: 1527-1530. |
| 4/9/08 | Ohn Chow | Bastow et al. (2004) Vernalization requires epigenetic silencing of FLC by histone methylation. Nature 427: 164-167. |
| 4/16/08 | Dan Clark | Dodd et al. (2005) Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science 309: 630-633. |
| 4/23/08 | Stephen Cheng | Molinier et al. (2006) Transgeneration memory of stress in plants. Nature 442: 1046-1049. |
| 4/30/08 | Tom Cohen | Harjes et al. (2008) Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification. Science 319: 330-333. |
| 5/7/08 | Rafael Gomez-Amaro | Chinchilla et al. (2007) A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature 448: 497-500. |
| 5/14/08 | Eveline Sun | Toby et al. (2008) cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids. PNAS 105: 4553-4558. |
| 5/21/08 | Morgan Pence | Manning et al. (2006) A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening. Nature Genetics 38: 948-952. |
| 5/28/08 | Marie Reichert |
Palatnik et al. (2003) Control of leaf morphogenesis by microRNAs. Nature 425: 257-263. |
| 6/4/08 | Stephanie Nissen | Fujimoto et al. (2008) Evolution and control of imprinted FWA genes in the genus Arabidopsis. PLoS Genetics 4: e1000048. |
| 6/11/08 | Shannon Weiman | Kimura et al (2008) Natural variation in leaf morphology results from mutation of a novel KNOX gene. Current Biol. |
Faculty: Bruce Hamilton (Course Director), Steve Dowdy, Larry Goldstein, Yishi Jin, Jing Yang