Topics 2009-2010
| Date | Presenter | Paper |
| 9/30/09 |
Organizational meeting |
Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper. |
Fall 2009: Unusual or Unexplained Patterns of Inheritance
| Date | Presenter | Paper |
| 10/7/09 | Dan Clark why do some disorders with high heritability have so little of the variance explained? |
Smith et al. (2009) Genome-wide association study of bipolar disorder in European American and African American individuals. Mol. Psych. 14: 755-763. |
| 10/21/09 | Tom Cohen | Nejentsev et al. (2009) Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes. Science 324: 387-389. |
| 10/28/09 | Rafael Gomez-Amaro | Rangwala et al. (2006) Meiotically Stable Natural Epialleles of Sadhu, a Novel Arabidopsis Retroposon. PLoS Genetics 2: e36. |
| 11/4/09 | Stephanie Nissen | Chong et al. (2007) Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics 39: 614-622. |
| 11/11/09 | Dr. Michael Kalichman | Discussion - Ethics and Animals. |
| 11/18/09 | Britt Flaherty | Rassoulzadegan et al. (2006) RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse. Nature 441: 469-474. |
| Thanksgiving | ||
| 12/2/09 | Morgan Pence | Zhang et al. (2008) A Genome-Wide Transcription Analysis Reveals a Close Correlation of Promoter INDEL Polymorphism and Heterotic Gene Expression in Rice Hybrids. Molec. Plant 5: 720-731. |
| 12/9/09 | Taylor Bright | Tonkin et al (2009) Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol 7: e1000084. |
| 12/16/09 |
Eveline Arnold |
Du et al. (2008) Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Nature Genetics 40: 460-465. |
| Winter Break |
Winter 2010: Non-coding RNAs
| Date | Presenter | Paper |
| 1/6/10 | David Kochman |
Figueroa-Bossi et al. (2009) Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target. Genes & Dev. 23: 2004-2015. |
| 1/13/10 | Deanna Stevens | Lee et al. (2009) A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes & Dev. 23: 2639-2649. |
| 1/20/10 | Jeff Nelson | Dinger et al. (2008) Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. Genome Research 18: 1433-1445. |
| 1/27/10 | Pagkapol Pongsawakul | Lanford et al. (2010) Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection.Science 327: 198-201. |
| 2/3/10 | Erilynn Russo | Ray et al. (2009) A stress-responsive RNA switch regulates VEGFA expression. Nature 457: 915-919. |
| 2/10/10 | Julianne McCall | Wayman et al. (2008) An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.PNAS 105: 9093-9098. |
| 2/17/10 | Emily Witham | Kim et al. (2007) A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons. Science 317: 1220-1224. |
| 2/24/10 | Gordon Bean | Yoo et al. (2009) MicroRNA-mediated switching of chromatin-remodelling complexes in neural development.Nature 460: 642-646. |
| 3/3/10 | Anne Conway | Khalil et al. (2009) Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. PNAS 106: 11667-11672. |
| 3/10/10 |
Dr. Fred Bonkovsky |
Ethics discussion: Gene Therapy and the Jesse Gelsinger case. |
| 3/17/10 | Mary Winn |
Kishore et al. (2010) The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing. Hum Mol Genet |
| Spring Break |
Spring 2010: Host-Pathogen Interactions
| Date | Presenter | Paper |
| 3/31/10 | Michael Lam | Marraffini and Sontheimer (2010) Self versus non-self discrimination during CRISPR RNA-directed immunity.Nature 463: 568-571. |
| 4/7/10 | Mark Moyle | Lacombe et al. (2010) Interfamily transfer of a plant pattern-recognition receptor confers broad-spectrum bacterial resistance. Nature Biotech. Epub ahead of print. doi:10.1038/nbt.1613 |
| 4/14/10 | Chloe Rivera | Carette et al. (2009) Haploid genetic screens in human cells identify host factors used by pathogens. Science 326:1231-1235. |
| 4/21/10 | Thomas Stark | Arbuckle et al. (2010) The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro. PNAS 107: 5563-5568. |
| 4/28/10 | Melissa Wilbert | Feng et al. (2008) Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 319:1096-1100. |
| 5/5/10 | Susan Zhang | König et al. (2010) Human host factors required for influenza virus replication. Nature 463: 813-817. |
| 5/12/10 | Tom Cohen | Horie et al. (2010) Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 463: 84-87. |
| 5/19/10 | Morgan Pence | Liu et al. (2005) Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J. Exp. Med. 202: 209-215. |
| 5/26/10 | Dr. Michael Caligiur |
Human subjects in research: ethics and professional responsibilities.
|
| 6/3/10 | Annual Retreat Dr. Stephen Warren, Emory University Dr. Hamilton Smith, J.Craig Venter Institute |
Faculty: Bruce Hamilton (Program Director), Richard Kolodner (Associate Director), Ted Friedmann, Trey Ideker, Jonathan Sebat, Al La Spada, Elizabeth Winzeler, Gene Yeo, Ben Yu, Michael Kalichman, Fred Bonkovsky, Michael Caligiuri