| Date | Presenter | Paper |
| 9/30/15 |
Organizational meeting |
Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper. |
| Date | Presenter | Paper |
| 10/7/15 | Victoria Corey | Macosko et al. (2015) Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214. |
| 10/14/15 | Alexandra Buckley | Newman et al. (2015) Robust enumeration of cell subsets from tissue expression profiles. Nature Methods 12, 453-457. |
| 10/21/15 | Sophia Espanola | Nihongaki et al. (2015) Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol. 33, 755-760. |
| 10/28/15 | Bernardo Lara | Yang et al. (2015) Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics 47, 1114–1120. |
| 11/4/15 | Kevin Ross | Starita et al. (2015) Massively parallel functional analysis of BRCA1 RING domain variants. Genetics 200, 413-422. |
| 11/11/15 | Genevieve Ryan | Tang et al. (2015) Cell type–specific manipulation with GFP-dependent Cre recombinase. Nature Neuroscience 18, 1334-1341. |
| 11/18/15 | Sam Stoner | Shi et al. (2015) Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains. Nat Biotechnol. 33, 661-667. |
| Thanksgiving | ||
| 12/2/15 | Anthony Schmitt | Kind et al. (2015) Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells. Cell 161, 134-147. |
| 12/9/15 | Gene Yeo, Al La Spada | Responsible Conduct of Research: The changing landscape of scientific publishing |
| Winter Break | Selection of Winter topic. |
| Date | Presenter | Paper |
| 1/6/16 | Danny Antaki | Harley et al. (2015) TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nature Genetics 48, 36-43. |
| 1/13/16 | Daniel Chen |
Kang et al. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349, aaa5612. See also Perspective by Cassidy and Narita. |
| 1/20/16 | Wilmer Del Cid | Lee et al. (2012) Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nature Neuroscience15, 819-826. |
| 1/27/16 | Kristin Withers | Wang et al. (2014) Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease. PNAS 111, 14454-14459. |
| 2/3/16 | Elaine Guo | Sanjiv et al. (2016) Cancer-specific synthetic lethality between ATR and CHK1 kinase activities. Cell Reports 14, 298-309. |
| 2/10/16 | Jennifer Kuo | Jiang et al. (2015) Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biol. 17, 1158-1168. |
| 2/17/16 | Terry Solomon | Cockram (2015) Quantitative genomic analysis of RecA protein binding during DNA double-strand break repair reveals RecBCD action in vivo.PNAS 112, E4735-E4742. |
| 2/24/16 | Jenhan Tao | Epshtein et al. (2014) UvrD facilitates DNA repair by pulling RNA polymerase backwards. Nature 505, 372-377. |
| 3/2/16 | Tina Wang | Matsumura et al. (2016) Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science 351, DOI: 10.1126/science.aad4395. |
| 3/9/16 |
|
Responsible Conduct of Research: The International Summit on Human Gene Editing Meeting Slides and Webcasts, Meeting in Brief |
| Spring Break | Selection of Spring topic. |
| Date | Presenter | Paper |
| 3/30/16 | Michael Baughn | Hilton et al. (2015) Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nature Biotechnology 33, 510-517. |
| 4/6/16 | Spencer Goodman | Shin et al. (2016) A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells.PLOS Genetics 12, e1005884. |
| 4/13/16 | Samuel Lin | Cohen et al. (2016) A role for the bacterial GATC methylome in antibiotic stress survival. Nature Geneticsdoi:10.1038/ng.3530 |
| 4/20/16 | Alannah Miranda | Hannon et al. (2016) Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nature Neuroscience 19, 48-54. |
| 4/25/16 | GTP ANNUAL RETREAT | Keynotes by Eric Green (NHGRI) and Sarah Tishkoff (U Penn). Research talks from J. Ecker, B. Hammerling, F. Martinez, A. Muotri, M. Parast, A. Pasquinelli, G. Pratt, M. Wilkinson, & M. Yu. |
| 4/27/16 | Shanna Newton | Wang et al. (2016) SIRT6 controls hematopoietic stem cell homeostasis through epigenetic regulation of Wnt signaling.Cell Stem Cell 18, 495–507. |
| 5/4/16 | Alison Parisian | Krishnakumar et al. (2016) FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity. Cell Stem Cell 18, 104-117 |
| 5/11/16 | Brian Reilly | Bintu et al. (2016) Dynamics of epigenetic regulation at the single cell level. Science351, 720-724. |
| 5/18/16 | Emily Wheeler | Dominissini et al. (2016) The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA. Nature 530, 441-446. |
| 5/25/16 | Prof.s Ackerman, Field, Frazer, Ideker, Joiner, Pillus, Troemel, Winzeler | Responsible Conduct of Research: How to Peer Review Some fodder: Vale (2012) Walbot (2009) |
