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Topics 2014-2015

Date Presenter Paper
10/8/14

Organizational meeting
Biomedical Research Facility II - 1104 8:00 am

 Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper.

Fall 2014: Classic Papers

Date Presenter Paper
10/15/14 Babette Hammerling Meselson and Stahl (1958) The replication of DNA in Escherichiacoli. PNAS44: 671-682. [pdf]
10/22/14 Cynthia Hsu Brenner, Jacob, and Meselson (1961) An unstable intermediate carrying information form genes to ribosomes for protein synthesis. Nature 190: 576-581. [pdf]
10/29/14 Fernando Martinez Jackson, Symons and Berg (1972) Biochemical method for inserting new genetic information into DNA of Simian Virus 40: Circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. PNAS . [pdf]
11/5/14 Jaime Barea Beadle, G.W. and Tatum, E.L. (1941) Genetic control of biochemical reactions in Neurospora. PNAS 27: 499-506. [pdf]
11/12/14 Prof. Nik Schork

Responsible Conduct of Research: Managing Conflicts of Interest.
11/19/14 Micah Manary Sturetevant (1913) The linear arrangement of six sex-linked factors in Drosophila as shown by their mode of association. J. Exp. Zool. 14: 43-59.
journal [pdf] E.S.P. reprint [pdf]
Thanksgiving
12/3/14 Gabriel Pratt Needleman and Wunsch (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J. Mol. Biol. 43: 443-453. [pdf]
12/10/14 Eric Scott Sanger et al. (1977) Nucleotide sequence of bacteriophage phiX174 DNA.Nature 265: 687-695. [pdf]
12/17/14 Naomi Searle Hartwell, Culotti, and Reid. (1970) Genetic Control of the Cell-Division cycle in Yeast, I. Detection of Mutants. PNAS 66: 352-359. [pdf]
Winter Break Selection of Winter topic.

Winter 2015: Population Genetics

Date Presenter Paper
1/7/15 Michael Yu Huerta-Sánchez et al. (2014) Altitude adaptation in Tibetans casued by introgression of Denisovan-like DNA. Nature 512, 194–197.
1/14/15 Alexandra Buckley

Schaub et al. (2012) Linking disease associations with regulatory information in the human genome (Method). Genome Research 22, 1748-1759.
1/21/15 Victoria Corey Tishkoff et al. (2001) Haplotype Diversity and Linkage Disequilibrium at Human G6PD: Recent Origin of Alleles That Confer Malarial Resistance.Science 293, 455-462.
1/28/15 Sophia Española Gurdasani et al (2015) The African Genome Variation Project shapes medical genetics in Africa. Nature 517, 327-332.
2/4/15 Kevin Ross Simons et al. (2014) The deleterious mutation load is insensitive to recent population history. Nature Genetics 46, 220-224.
2/11/15 Bernardo Lara King et al. (2015) Mosaic structural variation in children with developmental disorders. Human Mol. Genet. [pdf ahead of print]
2/18/15

Prof. Anthony Magit, MD, MPH
Director, Human Research Protection Program

 Use of human subjects in genetics research.
2/25/15 Genevieve Ryan Schubert et al. (2014) Prehistoric genomes reveal the genetic foundation and cost of horse domestication. PNAS 111, E5661–E5669.
3/4/15 Sam Stoner Lamichhaney et al. (2015) Evolution of Darwin's finches and their beaks revealed by genome sequencing. Nature 518, 371-375.
3/11/15


Anthony Schmitt

 Carbone et al. (2014) Gibbon genome and the fast karyotype evolution of small apes. Nature 513, 195-201.
Spring Break

Spring 2015: Agricultural Genetics

Date Presenter Paper
4/1/15 Lawrence Wong Shaatiel et al. (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnology Journal 5, 579-590.
4/8/15 Danny Antaki Pelsy et al. (2015) Chromosome replacement and deletion lead to clonal polymorphism of berry color in grapevine. PLOS Genetics 11, e1005081.
4/15/15 Daniel Chen Lyall et al. (2011) Suppression of Avian Influenza Transmission in Genetically Modified Chickens. Science 331, 223-226 .
4/22/15 Wilmer Del Cid Zheng et al. (2015) Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science 347, 991-994.
4/29/15 Prof. Michael Kalichman

Responsible Conduct of Research. What are appropriate safeguards and standards for environmental release of engineered orgnaisms and human germline interventions?

Assigned Papers:

  1. Glantz and Bier (2015) The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Science, Xpress online.
  2. Baltimore et al. (2015) A prudent path forward for genomic engineering and germline gene modification. Science 348:36-38.
  3. Lanphier et al. (2015) Don't edit the human germ line. Nature 519: 410-411.
5/6/15 Jennifer Kuo Mandell et al. (2015) Biocontainment of genetically modified organisms by synthetic protein design. Nature 518, 55–60.
5/13/15
 Nathan Jameson Huang, X. et al. (2015) Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis. Nat. Commun. 6: 6258.
5/20/15 Terry Solomon Simcic et al. (2015) Recovery of native genetic background in admixed populations using haplotypes, phenotypes, and pedigree information - using cika cattle as a case breed. PLoS One. 10, e0123253.
5/27/15
 Jenhan Tao Wang et al. (2014) Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew. Nature Biotech.32, 947–951.
6/3/15 Tina Wang Kim et al. (2014) Genomic-scale exchange of mRNA between a parasitic plant and its hosts. Science 345, 808-811.

Faculty: Bruce Hamilton (Program Director), Richard Kolodner (Associate Director), Faculty Mentors.