Journal Club

Fall 2018 - Psychiatric Genetics

October 3: Organizational Meeting
Introductions, GTP advising committee, Program expectations, How to critique a paper, Selection of Fall topic.

October 10: Shereen Ghosh, Gleeson Lab
Wray et al. (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics 50, 668–681. [bioRxiv]

October 17: Nina Gao, Nizet Lab
Deshpande et al. (2017) Cellular Phenotypes in Human iPSC-Derived Neurons from a Genetic Model of Autism Spectrum Disorder. Cell Reports 21, 2678-2687. [open access article]

October 24: Elie Farah, Chi Lab
Forrest et al. (2017) Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. Cell Stem Cell. 21, 305-318. [open access article]

October 31: Natalie Hollingsworth, Oegema Lab
Scarpa et al. (2018) Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression. Sciences Advances 4, eaat1294. [PMC]

November 7: Ryan Marina, Yeo Lab
Dong et al. (2018) Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease. Nature Neuroscience 21, 1482-1492.

November 14: Caroline Sferrazza, Goldstein Lab
Skene et al. (2018) Genetic identification of brain cell types underlying schizophrenia. Nature Genetics 50, 825-833. [bioRxiv]

November 21: Thanksgiving Holiday

November 28: Mike Vaill, Varki Lab
Domínguez-Iturza et al. (2018) The autism and schizophrenia-associated protein CYFIP1 regulates bilateral brain connectivity. Pre-print [bioRxiv] [download pdf]

December 5: Abraham Palmer, Professor and Vice-Chair, Department of Psychiatry
Responsible Conduct of Research Discussion: Human germline selection and modification.

December 12: Mike Valdez, Sun Lab
The Brainstorm Consortium: Anttila et al. (2018) Analysis of shared heritability in common disorders of the brain. Science 360, eaap8757. [bioRxiv].
Select Winter topic.

Winter 2019 - Genetics of Domestication

January 9: Joshua Chiou, Gaulton Lab
Wu et al. (2018) Genomics of the origin and evolution of Citrus. Nature 554, 311-316. [open access article]

January 16: Ryan Geusz, Sander Lab
VanBuren et al. (2015) Origin and domestication of papaya Yh chromosome. Genome Research 25, 524-533. [PMC]

January 23: Emily Griffin, Ackerman Lab
Pendleton et al. (2018) Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication. BMC Biology 16, 64. [open access article]

January 30: Krystyna Kolodziej, Mukamel & Ren Labs
vonHoldt et al. (2017) Structural variants in genes associated with human Williams-Beuren syndrome underlie stereotypical hypersociability in domestic dogs. Science Advances 3, e1700398. [UCLA escholarship]

February 6: Madeline Luth, Winzeler Lab
Wang et al (2018) Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes). PNAS 115, 10398-10403. [bioRxiv]

February 20: Noorsher Ahmed, Yeo Lab
Cornejo et al. (2018) Population genomic analyses of the chocolate tree, Theobroma cacao L., provide insights into its domestication process. Communications Biology 1, 167. [open access article]

February 27: Saugat Poudel, Nizet Lab
Schubert et al. (2014) Prehistoric genomes reveal the genetic foundation and cost of horse domestication. PNAS 111, E5661-E5669. [PMC]

March 6: Responsible Conduct of Research Discussion
Faculty panel: Friedmann, Hamilton, Sun, Winzeler. Peer Review standards and practice.

COPE Ethical Guidelines for Peer Reviewers [pdf]

March 13: Xinzhu Zhou, Palmer Lab
Leathlobhair et al. (2018) The evolutionary history of dogs in the Americas. Science 361, 81-85. [preprint via Apollo]

Select Spring quarter topic.

Spring 2019 - Classic Papers

April 3: Melinda Beccari, Cleveland Lab

April 10: Tunmise Olayinka, Muotri Lab

April 17: Jessica Bloom, Rifkin Lab

April 245: Margaret Burns, Yeo Lab

May 1: Corina Elder, Pasquinelli Lab

May 8: Emily Ho, Mellon Lab
Beadle and Tatum (1941) Genetic control of biochemical reactions in Neurospora. PNAS 27, 499-506.

May 15: James Hocker, Ren Lab

May 232: Erin Ritchie, Jin Lab

May 29: Zeyang Shen, Glass Lab

June 5: Yilan Shi, Yeo Lab

June 12: Responsible Conduct of Research Discussion