Topics 2008-2009
| Date | Presenter | Paper |
| 10/1/08 |
Organizational meeting |
Introductions, GTP Student Advising Committee, Choose Fall topic, How to choose and critique a paper. |
Fall 2008: RNA Genetics
| Date | Presenter | Paper |
| 10/8/08 | Tom Cohen | Brouns et al. (2008) Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes. Science 321: 960-964. |
| 10/15/08 | Molly Bush | Merritt et al. (2008) 3' UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline. Current Biol.18: 1–7. |
| 10/22/08 | Ohn Chow | Lecellier et al. (2005) A Cellular MicroRNA Mediates Antiviral Defense in Human Cells. Science 308: 557-560. |
| 10/29/08 | Michael Kalichman | Case discussion: Human Subjects and Informed Consent in Genetic Research Resources for Research Ethics Education |
| 11/5/08 | Dan Clark | Chen and Zheng (2008) Identify alternative splicing events based on position-specific evolutionary conservation. PLoS ONE 3: e2806. |
| 11/12/08 | Rafael Gomez-Amaro | Tay et al. (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiationNature 455: 1124-1128. |
| 11/19/08 | Stephanie Nissen | Marengo and Wassarman (2008) A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing. RNA 14: 1681-1695. |
| Thanksgiving | ||
| 12/3/08 | Britt Flaherty | Goncalves et al. (2008) The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression. RNA 14: 2538-2549. |
| 12/10/08 | Morgan Pence | Saraiya and Wang (2008) snoRNA, a Novel Precursor of microRNA in Giardia lamblia. PLoS Pathogens 4: e1000224 |
| 12/17/08 |
Eveline Sun |
Lee et al. (2008) miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.Nature Neuroscience 11: 1137-1139. |
| Winter Break |
Winter 2009: Evolutionary and Comparative Genetics
| Date | Presenter | Paper |
| 1/14/09 | Taylor Bright |
Mu et al. (2005) Host Switch Leads to Emergence ofPlasmodium vivax Malaria in Humans. Mol. Biol. Evol. 22: 1686-1693. |
| 1/21/09 | Michael Kalichman |
Case discussion: Science and Public Policy |
| 1/28/09 | David Kochman | Smukalla et al. (2008) FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast. Cell135: 726-737. |
| 2/4/09 | Julianne McCall | Krause et al. (2007) The Derived FOXP2 Variant of Modern Humans Was Shared with Neandertals. Curr. Biol. 17: 1908-1912. |
| 2/11/09 | Jeff Nelson | Gerke et al. (2009) Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast.Science 323: 498 - 501. |
| 2/18/09 | Pagkapol Pongsawakul |
Tauber et al. (2007) Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster. Science316: 1895-1897. Sandrelli et al. (2007) A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster.Science 316: 1897-1900. |
| 2/25/09 | Erilynn Russo | Perry et al. (2008) Copy number variation and evolution in humans and chimpanzees. Genome Research 18: 1698-1710. |
| 3/4/09 | Deanna Stevens | Wang et al. (2009) Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance. BMC Evol. Biol. 9: 23 doi:10.1186/1471-2148-9-23 |
| 3/11/09 | Emily Witham | Haygood et al. (2007) Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution. Nature Genetics 39: 1140-1144. |
Spring 2009: Classic Papers in Genetics
| Date | Presenter | Paper |
| 3/18/09 | Ohn Chow | Luria and Delbrück (1943) Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics 28: 491-511. |
| Spring Break | ||
| 4/1/09 | Leah Boyer | McClintock (1950) The Origin and Behavior of Mutable Loci in Maize. PNAS 36: 344-355. |
| 4/8/09 | Tom Cohen | Hartwel et al. (1970) Genetic control of cell division in yeast, I. Detection of mutants. PNAS 66: 352-359. |
| 4/15/09 | Rafael Gomez-Amaro | Nüsslein-Volhard and Wieschaus (1980) Mutations affecting segmentnumber and polarity in Drosophila. Nature 287: 795-801. |
| 4/22/09 | Stephanie Nissen | Sturtevant (1913) The linear arrangement of six sex-linked factors in Drosophila, as shown by their mode of association.J. Exp. Zool. 14: 43-59. |
| 4/29/09 | Morgan Pence | Avery et al. (1944) Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Faction Isolated from Pneumococcus Type III. J. Exp. Med. 79: 137-158. |
| 5/6/09 | Eveline Sun | Lewis (1978) A gene complex controlling segmentation inDrosophila. Nature 276: 565-570. |
| 5/13/09 | Taylor Bright | Hershey and Chase (1952) Independent functions of viral protein and nucleic acid in growth of bacteriophage. J. Gen. Physiol. 36: 39-56. |
| 5/20/09 | Britt Flaherty | Fire et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811. |
| 5/27/09 | David Kochman | Muller (1918) Genetic variability, twin hybrids and constant hybrids, in a case of balanced lethal factors. Genetics 3: 422-499. |
| 6/3/09 | UCSD Institute for Genomic Medicine and J. Craig Venter Institute Joint Symposium |
"Genome Frontiers in Human Health and Disease" |
| 6/10/09 | Jeff Nelson | Pauling et al. (1949) Sickle Cell Anemia, a Molecular Disease. Science 110: 543-548. |
Faculty: Bruce Hamilton (Program Director), Richard Kolodner (Associate Director), Elizabeth Winzeler, Ben Yu, Tracy Johnson, Sylvia Evans, John Kelsoe, Michael Kalichman, Steve Briggs